Add selected results from doHMRF to the giotto object

addHMRF(
  gobject,
  spat_unit = NULL,
  feat_type = NULL,
  HMRFoutput,
  k = NULL,
  betas_to_add = NULL,
  hmrf_name = NULL
)

Arguments

gobject

giotto object

spat_unit

spatial unit

feat_type

feature type

HMRFoutput

HMRF output from doHMRF()

k

number of domains

betas_to_add

results from different betas that you want to add

hmrf_name

specify a custom name

Value

giotto object

Examples

g <- GiottoData::loadGiottoMini("visium")
#> 1. read Giotto object
#> 2. read Giotto feature information
#> 3. read Giotto spatial information
#> 3.1 read Giotto spatial shape information
#> 3.2 read Giotto spatial centroid information
#> 3.3 read Giotto spatial overlap information
#> 4. read Giotto image information
#> 
#> checking default envname 'giotto_env'
#> a system default python environment was found
#> Using python path:
#>  "/usr/bin/python3"
spat_genes <- binSpect(g)
#> 
#> This is the single parameter version of binSpect
#> 
#> 1. matrix binarization complete
#> 
#> 2. spatial enrichment test completed
#> 
#> 3. (optional) average expression of high
#>  expressing cells calculated
#> 
#> 4. (optional) number of high expressing cells
#>  calculated

output_folder <- file.path(tempdir(), "HMRF")
if (!file.exists(output_folder)) dir.create(output_folder, recursive = TRUE)

out <- doHMRF(
    g,
    spatial_genes = spat_genes[seq_len(20)]$feats,
    expression_values = "scaled",
    spatial_network_name = "Delaunay_network",
    k = 6, betas = c(0, 10, 5),
    output_folder = output_folder
)
#> Error: package 'smfishHmrf' is not yet installed
#> 
#>  To install:

g <- addHMRF(
    gobject = g,
    HMRFoutput = out,
    k = 6,
    betas_to_add = 20,
    hmrf_name = "HMRF"
)
#> Error in eval(expr, envir, enclos): object 'out' not found

spatPlot(
    gobject = g, cell_color = "HMRF_k6_b.20",
)
#> Error in (function (ggobject, instrs = NULL, sdimx = NULL, sdimy = NULL,     cell_locations_metadata_selected, cell_locations_metadata_other,     cell_color = NULL, color_as_factor = TRUE, cell_color_code = NULL,     cell_color_gradient = NULL, gradient_midpoint = NULL, gradient_style = "divergent",     gradient_limits = NULL, select_cell_groups = NULL, select_cells = NULL,     point_size = 2, point_alpha = 1, point_border_col = "lightgrey",     point_border_stroke = 0.1, show_cluster_center = FALSE, show_center_label = TRUE,     center_point_size = 4, center_point_border_col = "black",     center_point_border_stroke = 0.1, label_size = 4, label_fontface = "bold",     show_other_cells = TRUE, other_cell_color = "lightgrey",     other_point_size = 1, show_legend = TRUE) {    if (is.null(sdimx) || is.null(sdimy)) {        warning(wrap_txt("plot_method = ggplot,\n                        but spatial dimensions for sdimx and/or sdimy\n                        are not specified. It will default to the\n                        'sdimx' and 'sdimy' "))        sdimx <- "sdimx"        sdimy <- "sdimy"    }    point_size <- as.numeric(point_size)    point_alpha <- as.numeric(point_alpha)    point_border_stroke <- as.numeric(point_border_stroke)    center_point_size <- as.numeric(center_point_size)    center_point_border_stroke <- as.numeric(center_point_border_stroke)    label_size <- as.numeric(label_size)    other_point_size <- as.numeric(other_point_size)    pl <- ggobject    if ((!is.null(select_cells) || !is.null(select_cell_groups)) &&         isTRUE(show_other_cells)) {        pl <- pl + ggplot2::geom_point(data = cell_locations_metadata_other,             aes_string(x = sdimx, sdimy), color = other_cell_color,             show.legend = FALSE, size = other_point_size, alpha = point_alpha)    }    if (is.null(cell_color)) {        cell_color <- "lightblue"        pl <- pl + ggplot2::geom_point(data = cell_locations_metadata_selected,             aes_string(x = sdimx, y = sdimy), show.legend = show_legend,             shape = 21, fill = cell_color, size = point_size,             stroke = point_border_stroke, color = point_border_col,             alpha = point_alpha)    }    else if (length(cell_color) > 1L) {        if (is.numeric(cell_color) || is.factor(cell_color)) {            if (nrow(cell_locations_metadata_selected) != length(cell_color)) {                stop("\n vector needs to be the same lengths as\n                    number of cells \n")            }            cell_locations_metadata_selected[["temp_color"]] <- cell_color            pl <- pl + ggplot2::geom_point(data = cell_locations_metadata_selected,                 aes_string2(x = sdimx, y = sdimy, fill = "temp_color"),                 show.legend = show_legend, shape = 21, size = point_size,                 color = point_border_col, stroke = point_border_stroke,                 alpha = point_alpha)        }        else if (is.character(cell_color)) {            if (!all(cell_color %in% grDevices::colors())) {                stop("cell_color is not numeric,\n                    a factor or vector of colors \n")            }            pl <- pl + ggplot2::geom_point(data = cell_locations_metadata_selected,                 aes_string2(x = sdimx, y = sdimy), show.legend = show_legend,                 shape = 21, fill = cell_color, size = point_size,                 color = point_border_col, stroke = point_border_stroke,                 alpha = point_alpha)        }    }    else if (is.character(cell_color)) {        if (!cell_color %in% colnames(cell_locations_metadata_selected)) {            if (!cell_color %in% grDevices::colors()) {                stop(cell_color, " is not a color or a column name \n")            }            pl <- pl + ggplot2::geom_point(data = cell_locations_metadata_selected,                 aes_string2(x = sdimx, y = sdimy), show.legend = show_legend,                 shape = 21, fill = cell_color, size = point_size,                 color = point_border_col, stroke = point_border_stroke,                 alpha = point_alpha)        }        else {            class_cell_color <- class(cell_locations_metadata_selected[[cell_color]])            if ((class_cell_color %in% c("integer", "numeric")) &&                 !isTRUE(color_as_factor)) {                if (!is.null(gradient_limits) && is.vector(gradient_limits) &&                   length(gradient_limits) == 2) {                  lower_lim <- gradient_limits[[1]]                  upper_lim <- gradient_limits[[2]]                  numeric_data <- cell_locations_metadata_selected[[cell_color]]                  limit_numeric_data <- ifelse(numeric_data >                     upper_lim, upper_lim, ifelse(numeric_data <                     lower_lim, lower_lim, numeric_data))                  cell_locations_metadata_selected[[cell_color]] <- limit_numeric_data                }                pl <- pl + ggplot2::geom_point(data = cell_locations_metadata_selected,                   aes_string2(x = sdimx, y = sdimy, fill = cell_color),                   show.legend = show_legend, shape = 21, size = point_size,                   color = point_border_col, stroke = point_border_stroke,                   alpha = point_alpha)            }            else {                if (isTRUE(color_as_factor)) {                  factor_data <- factor(cell_locations_metadata_selected[[cell_color]])                  cell_locations_metadata_selected[[cell_color]] <- factor_data                }                if (isTRUE(show_cluster_center) || isTRUE(show_center_label)) {                  annotated_DT_centers <- cell_locations_metadata_selected[,                     .(center_1 = stats::median(get("sdimx")),                       center_2 = stats::median(get("sdimy"))),                     by = cell_color]                  factor_center_data <- factor(annotated_DT_centers[[cell_color]])                  annotated_DT_centers[[cell_color]] <- factor_center_data                }                pl <- pl + ggplot2::geom_point(data = cell_locations_metadata_selected,                   aes_string2(x = sdimx, y = sdimy, fill = cell_color),                   show.legend = show_legend, shape = 21, size = point_size,                   color = point_border_col, stroke = point_border_stroke,                   alpha = point_alpha)                if (isTRUE(show_cluster_center) && (isTRUE(color_as_factor) ||                   class_cell_color %in% c("character", "factor"))) {                  pl <- pl + ggplot2::geom_point(data = annotated_DT_centers,                     aes_string2(x = "center_1", y = "center_2",                       fill = cell_color), color = center_point_border_col,                     stroke = center_point_border_stroke, size = center_point_size,                     shape = 21, alpha = point_alpha)                }                if (isTRUE(show_center_label)) {                  pl <- pl + ggrepel::geom_text_repel(data = annotated_DT_centers,                     aes_string2(x = "center_1", y = "center_2",                       label = cell_color), size = label_size,                     fontface = label_fontface)                }            }            if (!is.null(cell_color_code)) {                pl <- pl + ggplot2::scale_fill_manual(values = cell_color_code)            }            else if (isTRUE(color_as_factor)) {                number_colors <- length(unique(factor_data))                cell_color_code <- set_default_color_discrete_cell(instrs = instrs)(n = number_colors)                names(cell_color_code) <- unique(factor_data)                pl <- pl + ggplot2::scale_fill_manual(values = cell_color_code)            }            else if (!isTRUE(color_as_factor)) {                if (is.null(gradient_midpoint)) {                  gradient_midpoint <- stats::median(cell_locations_metadata_selected[[cell_color]])                }                pl <- pl + set_default_color_continuous_cell(colors = cell_color_gradient,                   instrs = instrs, style = gradient_style, midpoint = gradient_midpoint,                   type = "fill", )            }        }    }    return(pl)})(ggobject = structure(list(data = structure(list(), class = "waiver"),     layers = list(), scales = <environment>, guides = <environment>,     mapping = structure(list(), names = character(0), class = "uneval"),     theme = structure(list(line = structure(list(colour = "black",         linewidth = 0.5, linetype = 1, lineend = "butt", arrow = FALSE,         inherit.blank = TRUE), class = c("element_line", "element"    )), rect = structure(list(fill = "white", colour = "black",         linewidth = 0.5, linetype = 1, inherit.blank = TRUE), class = c("element_rect",     "element")), text = structure(list(family = "", face = "plain",         colour = "black", size = 11, hjust = 0.5, vjust = 0.5,         angle = 0, lineheight = 0.9, margin = structure(c(0,         0, 0, 0), unit = 8L, class = c("margin", "simpleUnit",         "unit", "unit_v2")), debug = FALSE, inherit.blank = TRUE), class = c("element_text",     "element")), title = NULL, aspect.ratio = NULL, axis.title = NULL,         axis.title.x = structure(list(family = NULL, face = NULL,             colour = NULL, size = NULL, hjust = NULL, vjust = 1,             angle = NULL, lineheight = NULL, margin = structure(c(2.75,             0, 0, 0), unit = 8L, class = c("margin", "simpleUnit",             "unit", "unit_v2")), debug = NULL, inherit.blank = TRUE), class = c("element_text",         "element")), axis.title.x.top = structure(list(family = NULL,             face = NULL, colour = NULL, size = NULL, hjust = NULL,             vjust = 0, angle = NULL, lineheight = NULL, margin = structure(c(0,             0, 2.75, 0), unit = 8L, class = c("margin", "simpleUnit",             "unit", "unit_v2")), debug = NULL, inherit.blank = TRUE), class = c("element_text",         "element")), axis.title.x.bottom = NULL, axis.title.y = structure(list(            family = NULL, face = NULL, colour = NULL, size = NULL,             hjust = NULL, vjust = 1, angle = 90, lineheight = NULL,             margin = structure(c(0, 2.75, 0, 0), unit = 8L, class = c("margin",             "simpleUnit", "unit", "unit_v2")), debug = NULL,             inherit.blank = TRUE), class = c("element_text",         "element")), axis.title.y.left = NULL, axis.title.y.right = structure(list(            family = NULL, face = NULL, colour = NULL, size = NULL,             hjust = NULL, vjust = 1, angle = -90, lineheight = NULL,             margin = structure(c(0, 0, 0, 2.75), unit = 8L, class = c("margin",             "simpleUnit", "unit", "unit_v2")), debug = NULL,             inherit.blank = TRUE), class = c("element_text",         "element")), axis.text = structure(list(family = NULL,             face = NULL, colour = "grey30", size = structure(0.8, class = "rel"),             hjust = NULL, vjust = NULL, angle = NULL, lineheight = NULL,             margin = NULL, debug = NULL, inherit.blank = TRUE), class = c("element_text",         "element")), axis.text.x = structure(list(family = NULL,             face = NULL, colour = NULL, size = NULL, hjust = NULL,             vjust = 1, angle = NULL, lineheight = NULL, margin = structure(c(2.2,             0, 0, 0), unit = 8L, class = c("margin", "simpleUnit",             "unit", "unit_v2")), debug = NULL, inherit.blank = TRUE), class = c("element_text",         "element")), axis.text.x.top = structure(list(family = NULL,             face = NULL, colour = NULL, size = NULL, hjust = NULL,             vjust = 0, angle = NULL, lineheight = NULL, margin = structure(c(0,             0, 2.2, 0), unit = 8L, class = c("margin", "simpleUnit",             "unit", "unit_v2")), debug = NULL, inherit.blank = TRUE), class = c("element_text",         "element")), axis.text.x.bottom = NULL, axis.text.y = structure(list(            family = NULL, face = 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class = c("margin",             "simpleUnit", "unit", "unit_v2")), debug = NULL,             inherit.blank = TRUE), class = c("element_text",         "element")), axis.ticks = structure(list(colour = "grey20",             linewidth = NULL, linetype = NULL, lineend = NULL,             arrow = FALSE, inherit.blank = TRUE), class = c("element_line",         "element")), axis.ticks.x = NULL, axis.ticks.x.top = NULL,         axis.ticks.x.bottom = NULL, axis.ticks.y = NULL, axis.ticks.y.left = NULL,         axis.ticks.y.right = NULL, axis.ticks.theta = NULL, axis.ticks.r = NULL,         axis.minor.ticks.x.top = NULL, axis.minor.ticks.x.bottom = NULL,         axis.minor.ticks.y.left = NULL, axis.minor.ticks.y.right = NULL,         axis.minor.ticks.theta = NULL, axis.minor.ticks.r = NULL,         axis.ticks.length = structure(2.75, unit = 8L, class = c("simpleUnit",         "unit", "unit_v2")), axis.ticks.length.x = NULL, axis.ticks.length.x.top = NULL,         axis.ticks.length.x.bottom = NULL, axis.ticks.length.y = NULL,         axis.ticks.length.y.left = NULL, axis.ticks.length.y.right = NULL,         axis.ticks.length.theta = NULL, axis.ticks.length.r = NULL,         axis.minor.ticks.length = structure(0.75, class = "rel"),         axis.minor.ticks.length.x = NULL, axis.minor.ticks.length.x.top = NULL,         axis.minor.ticks.length.x.bottom = NULL, axis.minor.ticks.length.y = NULL,         axis.minor.ticks.length.y.left = NULL, axis.minor.ticks.length.y.right = NULL,         axis.minor.ticks.length.theta = NULL, axis.minor.ticks.length.r = NULL,         axis.line = structure(list(), class = c("element_blank",         "element")), axis.line.x = NULL, axis.line.x.top = NULL,         axis.line.x.bottom = NULL, axis.line.y = NULL, axis.line.y.left = NULL,         axis.line.y.right = NULL, axis.line.theta = NULL, axis.line.r = NULL,         legend.background = structure(list(fill = NULL, colour = NA,             linewidth = NULL, linetype = NULL, inherit.blank = TRUE), class = c("element_rect",         "element")), legend.margin = structure(c(5.5, 5.5, 5.5,         5.5), unit = 8L, class = c("margin", "simpleUnit", "unit",         "unit_v2")), legend.spacing = structure(11, unit = 8L, class = c("simpleUnit",         "unit", "unit_v2")), legend.spacing.x = NULL, legend.spacing.y = NULL,         legend.key = NULL, legend.key.size = structure(1.2, unit = 3L, class = c("simpleUnit",         "unit", "unit_v2")), legend.key.height = NULL, legend.key.width = NULL,         legend.key.spacing = structure(5.5, unit = 8L, class = c("simpleUnit",         "unit", "unit_v2")), legend.key.spacing.x = NULL, legend.key.spacing.y = NULL,         legend.frame = NULL, legend.ticks = NULL, legend.ticks.length = structure(0.2, class = "rel"),         legend.axis.line = NULL, legend.text = structure(list(            family = NULL, face = NULL, colour = NULL, size = structure(0.8, class = "rel"),             hjust = NULL, vjust = NULL, angle = NULL, lineheight = NULL,             margin = NULL, debug = NULL, inherit.blank = TRUE), class = c("element_text",         "element")), legend.text.position = NULL, legend.title = structure(list(            family = NULL, face = NULL, colour = NULL, size = NULL,             hjust = 0, vjust = NULL, angle = NULL, lineheight = NULL,             margin = NULL, debug = NULL, inherit.blank = TRUE), class = c("element_text",         "element")), legend.title.position = NULL, legend.position = "right",         legend.position.inside = NULL, legend.direction = NULL,         legend.byrow = NULL, legend.justification = "center",         legend.justification.top = NULL, legend.justification.bottom = NULL,         legend.justification.left = NULL, legend.justification.right = NULL,         legend.justification.inside = NULL, legend.location = NULL,         legend.box = NULL, legend.box.just = NULL, legend.box.margin = structure(c(0,         0, 0, 0), unit = 1L, class = c("margin", "simpleUnit",         "unit", "unit_v2")), legend.box.background = structure(list(), class = c("element_blank",         "element")), legend.box.spacing = structure(11, unit = 8L, class = c("simpleUnit",         "unit", "unit_v2")), panel.background = structure(list(            fill = "white", colour = NA, linewidth = NULL, linetype = NULL,             inherit.blank = TRUE), class = c("element_rect",         "element")), panel.border = structure(list(fill = NA,             colour = "grey20", linewidth = NULL, linetype = NULL,             inherit.blank = TRUE), class = c("element_rect",         "element")), panel.spacing = structure(5.5, unit = 8L, class = c("simpleUnit",         "unit", "unit_v2")), panel.spacing.x = NULL, panel.spacing.y = NULL,         panel.grid = structure(list(colour = "grey92", linewidth = NULL,             linetype = NULL, lineend = NULL, arrow = FALSE, inherit.blank = TRUE), class = c("element_line",         "element")), panel.grid.major = NULL, panel.grid.minor = structure(list(            colour = NULL, linewidth = structure(0.5, class = "rel"),             linetype = NULL, lineend = NULL, arrow = FALSE, inherit.blank = TRUE), class = c("element_line",         "element")), panel.grid.major.x = NULL, panel.grid.major.y = NULL,         panel.grid.minor.x = NULL, panel.grid.minor.y = NULL,         panel.ontop = FALSE, plot.background = structure(list(            fill = NULL, colour = "white", linewidth = NULL,             linetype = NULL, inherit.blank = TRUE), class = c("element_rect",         "element")), plot.title = structure(list(family = NULL,             face = NULL, colour = NULL, size = structure(1.2, class = "rel"),             hjust = 0, vjust = 1, angle = NULL, lineheight = NULL,             margin = structure(c(0, 0, 5.5, 0), unit = 8L, class = c("margin",             "simpleUnit", "unit", "unit_v2")), debug = NULL,             inherit.blank = TRUE), class = c("element_text",         "element")), plot.title.position = "panel", plot.subtitle = structure(list(            family = NULL, face = NULL, colour = NULL, size = NULL,             hjust = 0, vjust = 1, angle = NULL, lineheight = NULL,             margin = structure(c(0, 0, 5.5, 0), unit = 8L, class = c("margin",             "simpleUnit", "unit", "unit_v2")), debug = NULL,             inherit.blank = TRUE), class = c("element_text",         "element")), plot.caption = structure(list(family = NULL,             face = NULL, colour = NULL, size = structure(0.8, class = "rel"),             hjust = 1, vjust = 1, angle = NULL, lineheight = NULL,             margin = structure(c(5.5, 0, 0, 0), unit = 8L, class = c("margin",             "simpleUnit", "unit", "unit_v2")), debug = NULL,             inherit.blank = TRUE), class = c("element_text",         "element")), plot.caption.position = "panel", plot.tag = structure(list(            family = NULL, face = NULL, colour = NULL, size = structure(1.2, class = "rel"),             hjust = 0.5, vjust = 0.5, angle = NULL, lineheight = NULL,             margin = NULL, debug = NULL, inherit.blank = TRUE), class = c("element_text",         "element")), plot.tag.position = "topleft", plot.tag.location = NULL,         plot.margin = structure(c(5.5, 5.5, 5.5, 5.5), unit = 8L, class = c("margin",         "simpleUnit", "unit", "unit_v2")), strip.background = structure(list(            fill = "grey85", colour = "grey20", linewidth = NULL,             linetype = NULL, inherit.blank = TRUE), class = c("element_rect",         "element")), strip.background.x = NULL, strip.background.y = NULL,         strip.clip = "inherit", strip.placement = "inside", strip.text = structure(list(            family = NULL, face = NULL, colour = "grey10", size = structure(0.8, class = "rel"),             hjust = NULL, vjust = NULL, angle = NULL, lineheight = NULL,             margin = structure(c(4.4, 4.4, 4.4, 4.4), unit = 8L, class = c("margin",             "simpleUnit", "unit", "unit_v2")), debug = NULL,             inherit.blank = TRUE), class = c("element_text",         "element")), strip.text.x = NULL, strip.text.x.bottom = NULL,         strip.text.x.top = NULL, strip.text.y = structure(list(            family = NULL, face = NULL, colour = NULL, size = NULL,             hjust = NULL, vjust = NULL, angle = -90, lineheight = NULL,             margin = NULL, debug = NULL, inherit.blank = TRUE), class = c("element_text",         "element")), strip.text.y.left = structure(list(family = NULL,             face = NULL, colour = NULL, size = NULL, hjust = NULL,             vjust = NULL, angle = 90, lineheight = NULL, margin = NULL,             debug = NULL, inherit.blank = TRUE), class = c("element_text",         "element")), strip.text.y.right = NULL, strip.switch.pad.grid = structure(2.75, unit = 8L, class = c("simpleUnit",         "unit", "unit_v2")), strip.switch.pad.wrap = structure(2.75, unit = 8L, class = c("simpleUnit",         "unit", "unit_v2"))), class = c("theme", "gg"), complete = TRUE, validate = TRUE),     coordinates = <environment>, facet = <environment>, plot_env = <environment>,     layout = <environment>, labels = structure(list(), names = character(0))), class = c("gg", "ggplot")), instrs = structure(list(python_path = "/usr/bin/python3",     show_plot = TRUE, return_plot = FALSE, save_plot = FALSE,     save_dir = NA, plot_format = "png", dpi = 300, units = "in",     height = 9, width = 9, is_docker = FALSE, active_spat_unit = "cell",     active_feat_type = "rna"), class = "giottoInstructions"),     sdimx = "sdimx", sdimy = "sdimy", cell_locations_metadata_selected = structure(list(        cell_ID = c("AAAGGGATGTAGCAAG-1", "AAATGGCATGTCTTGT-1",         "AAATGGTCAATGTGCC-1", "AAATTAACGGGTAGCT-1", "AACAACTGGTAGTTGC-1",         "AACAGGAAATCGAATA-1", "AACAGGATGGGCCGCG-1", "AACCATGGGATCGCTA-1",         "AACCCAGAGACGGAGA-1", "AACCGAGCTTGGTCAT-1", "AACCGTTGTGTTTGCT-1",         "AACGATAGAAGGGCCG-1", "AACGATATGTCAACTG-1", "AACGCGGTCTCCAGCC-1",         "AACGTCAGACTAGTGG-1", "AACTCGATGGCGCAGT-1", "AACTGATATTAGGCCT-1",         "AACTGGGTCCCGACGT-1", "AACTTGCCCGTATGCA-1", "AAGAGATGAATCGGTA-1",         "AAGCTCGTGCCAAGTC-1", "AAGGAGCGGTTGGTGC-1", "AAGGCGCGTAAAGCTT-1",         "AAGGCTGTGCTCATCG-1", "AAGTAGAAGACCGGGT-1", "AAGTAGTGACGCGAGG-1",         "AATCCAAGGGCCTGAG-1", "AATGACTGTCAGCCGG-1", "AATGCAACCGGGTACC-1",         "AATGGTTCTCACAAGC-1", "AATTTGGTTCCAAAGA-1", "ACAACAGCATGAGCTA-1",         "ACAACGGTCCCTGCGA-1", "ACAAGGACAAGAGGTT-1", "ACACAAAGACGGGTGG-1",         "ACACACTTTCTACACG-1", "ACACCCAGCATGCAGC-1", "ACACCCGAGAAATCCG-1",         "ACACCTTAAGTAGGGC-1", "ACACGAGACTCCTTCT-1", "ACACGGGAACTTAGGG-1",         "ACATAATAAGGCGGTG-1", "ACCAAGAACGCGTGTC-1", "ACCACAAGTTTCTATC-1",         "ACCCTTCATCTGCGAA-1", "ACCGACTGAGTCCCAC-1", "ACCTAATCGACTTCCT-1",         "ACGATCATACATAGAG-1", "ACGCATTCGTGAGTAC-1", "ACGCCAGATGATTTCT-1",         "ACGCGGGCCAAGGACA-1", "ACGGAATTTAGCAAAT-1", "ACGTAGATTGCTGATG-1",         "ACGTGCGCCTCGTGCA-1", "ACGTTTAGTTGTGATC-1", "ACTACCAGCTCTCTGG-1",         "ACTATTCGTCCGTGGT-1", "ACTCAATAAAGGCACG-1", "ACTGCCGTCGTAACTC-1",         "ACTGTAGCACTTTGGA-1", "ACTGTCCAGGATTATA-1", "ACTGTCTTCTTTAGAA-1",         "ACTGTGCTAGTAGATC-1", "ACTTAGTACGACAAGA-1", "ACTTCGCCATACGCAC-1",         "ACTTGGGACCCGGTGG-1", "ACTTTCCTATAGCTTC-1", "AGAACGTGGTACATTC-1",         "AGACCATGGGATACAA-1", "AGACCCGCCCTCCTCG-1", "AGACTAGCCTTCCAGA-1",         "AGAGCGGGCTAATCAT-1", "AGAGCGTACAAGCTCG-1", "AGATAACTTCAGGGCC-1",         "AGATACGACTTCATAT-1", "AGATCTCAGGTGTGAT-1", "AGATGACTCGCCCACG-1",         "AGCACCAGTACTCACG-1", "AGCACTTAAGGACGCC-1", "AGCATCGTCGATAATT-1",         "AGCCCTAAGCGAAGTT-1", "AGCGACATCCCATTCA-1", "AGCGACCAACGATATT-1",         "AGCGGGAAGGGTCCAT-1", "AGCTATTTAATCCAAC-1", "AGGACATCGCACGTCG-1",         "AGGCCACCCGTTATGA-1", "AGGCCCATTGTACAGG-1", "AGGCTATGGTTAGCTT-1",         "AGGGCGTGATCGGCTA-1", "AGGGCTGCAGTTACAG-1", "AGGGTTTAGTTCGGGA-1",         "AGGTAACCTCCTATTC-1", "AGGTACGATATTGCCA-1", "AGGTAGGTACAAAGCT-1",         "AGGTTGAGGCACGCTT-1", "AGTAATGTCTTGCCGC-1", "AGTAGGTAACATACAT-1",         "AGTATAATACTAGGCA-1", "AGTCAGCCACCGCCTG-1", "AGTCGGCCCAAACGAC-1",         "AGTCTTCTCCTCAAAT-1", "AGTTCCTACAGAATTA-1", "AGTTTCGCAGGTCGGA-1",         "ATAAAGGCTCGGTCGT-1", "ATAACGGAGTCCAACG-1", "ATAATAGTGTAGGGAC-1",         "ATACCACGGGCAACTT-1", "ATACTAGCATGACCCT-1", "ATAGACGAAGAGAAAG-1",         "ATAGAGTACTGGGACA-1", "ATAGGGATATCCTTGA-1", "ATAGGTTGGGCAGATG-1",         "ATATCTTAGGGCCTTC-1", "ATATTCCCACAGGTCA-1", "ATATTGCTGTCAAAGT-1",         "ATATTTAACCCTCAAG-1", "ATCAATCTGGGCTGCA-1", "ATCACTTCATCCTCGC-1",         "ATCCAACGCAGTCATA-1", "ATCGACTCTTTCCGTT-1", "ATCGCACGCCGGGAGA-1",         "ATCTCCCTGCAATCTA-1", "ATCTGGTTAAGACTGT-1", "ATCTGTAATTGTACCC-1",         "ATCTTGACCTGCAACG-1", "ATGAAGCCAAGGAGCC-1", "ATGACGCCGGCTCTAA-1",         "ATGAGGAGTGTTAATC-1", "ATGATCGGGAATAGAC-1", "ATGCACTACCGCATTG-1",         "ATGCATGATCCAGGAT-1", "ATGCCGGTCTTGCATA-1", "ATGCGACAGTCCCATT-1",         "ATGCTCAGTGTTGCAT-1", "ATGGATTGACCAAACG-1", "ATGTGCATCCGACGCA-1",         "ATGTTACGAGCAATAC-1", "ATTAATACTACGCGGG-1", "ATTAATTCGGTCACTC-1",         "ATTACTAGCCTCTTGC-1", "ATTAGATTGATAGCGG-1", "ATTATGCCATAGGGAG-1",         "ATTCCTCCGCCAGTGC-1", "ATTCTCGTCTCTTTAG-1", "ATTGAAGATCTTAGTG-1",         "ATTGCTGCTCCTCCAT-1", "ATTGGGAATATCTTGG-1", "ATTTAACTCGTATTAC-1",         "ATTTACAGTTTACTGG-1", "ATTTGTTCCAGGGCTC-1", "CAAACGGTCGCACTTT-1",         "CAAACTATTGAGCTTC-1", "CAAATTGTCAGCAAGC-1", "CAACGACCCGTTTACA-1",         "CAACGGTTCTTGATAC-1", "CAACTCCTTGATCCCG-1", "CAAGCAACGTCGGAGT-1",         "CAAGCACCAAATGCCT-1", "CAATAAACCTTGGCCC-1", "CAATTAAGGGTGATGA-1",         "CACACAGGGATAGATT-1", "CACAGCACCCACGGCA-1", "CACAGCTAGGGAGTGA-1",         "CACCATCGGAGGAGAC-1", "CACCCACACGTCACCC-1", "CACCGCCAGAAGGTTT-1",         "CACCTAATCAGTTTAC-1", "CACCTCGATGGTGGAC-1", "CACGAAAGTTAGTCCC-1",         "CACGCACAGCGCAGCT-1", "CACGCAGCGAGGCTTT-1", "CACTAAAGTTGCCTAT-1",         "CACTCAGCTCTTGAGG-1", "CACTGTCCAAGTGAGA-1", "CACTTAATCAGACGGA-1",         "CACTTCGCCACAGGCT-1", "CAGAGCATGAGCTTGC-1", "CAGATACTAACATAGT-1",         "CAGCTCACTGAGACAT-1", "CAGCTCGTGCTTGTGT-1", "CAGCTTAGTAGGTAGC-1",         "CAGTGTCCGCAGAATG-1", "CAGTTCAAATTGACAC-1", "CATACAAAGCCGAACC-1",         "CATAGTAGCATAGTAG-1", "CATCATCTACCCGGAC-1", "CATCGCCCGCGGCCAA-1",         "CATGAACCGACATTTG-1", "CATGATGCACAATTCT-1", "CATGCGTTAGACAGAA-1",         "CATGCTGGCTCCAATT-1", "CATGGCAGGAAGATCG-1", "CATGGTCTAGATACCG-1",         "CATTACGTCGGCCCGT-1", "CATTATGCTTGTTGTG-1", "CCAAACAGAACCCTCG-1",         "CCAACGATGCACTGAT-1", "CCAAGACTTCTGCGAA-1", "CCAAGCGTAACTCGTA-1",         "CCAAGGAACAGAGAGG-1", "CCAATAGTGCCGTCGA-1", "CCAATTGAATGTTAAT-1",         "CCACGAGAAGAGAATC-1", "CCAGGGACGTGGCCTC-1", "CCATAAACAACCCGAC-1",         "CCATAGGTTGGCGTGG-1", "CCATCCATACCAAGTC-1", "CCATGCCTGTTTAGTA-1",         "CCATGCTCTGCAGGAA-1", "CCATTAGCGATAATCC-1", "CCATTCCCTGCCCACA-1",         "CCCGACCATAGTCCGC-1", "CCCGCCATGCTCCCGT-1", "CCCGTCAGCGTCTGAC-1",         "CCCTCATTCTGGAATT-1", "CCCTGAAATGAGTTGA-1", "CCGAAAGTGGTGAGCA-1",         "CCGCCGGTCAACACAC-1", "CCGGAATGGTTTCAGT-1", "CCGGCGCATATTGGAT-1",         "CCGGGACCCGCAGAGA-1", "CCGGGCGGTCTCGTCA-1", "CCGTACCCAAGCGCCA-1",         "CCGTGCCCATGACGGC-1", "CCTACGGCTCAGTCGA-1", "CCTACTGCTTACACTT-1",         "CCTAGTTAGTCGCATG-1", "CCTATGGGTTACCGTC-1", "CCTCACCAATCTTGAC-1",         "CCTCCGACAATTCAAG-1", "CCTCGAAGTGGACGGG-1", "CCTCGCCAGCAAATTA-1",         "CCTCTAATCTGCCAAG-1", "CCTCTCTCCCATCTAG-1", "CCTCTGGCCTAGACGG-1",         "CCTGAATATTTACATA-1", "CCTGCTATTTGAGAAG-1", "CCTGGCTAGACCCGCC-1",         "CCTGTCACCCGGGCTC-1", "CCTTCTTGATCCAGTG-1", "CGAACGCCCAGTGCCG-1",         "CGAAGTTGCTCTGTGT-1", "CGAGAGATGTGAACCT-1", "CGAGCGTTGATCAGCC-1",         "CGAGCTGGGCTTTAGG-1", "CGAGGCTAAATATGGC-1", "CGCAAACACGAGTTAC-1",         "CGCAATTACTTTCGGT-1", "CGCAATTAGGGTAATA-1", "CGCAATTCTACAATAA-1",         "CGCATTAGCTAATAGG-1", "CGCGCCCGACTTAATA-1", "CGCGTTCATGAAATAC-1",         "CGCTATACCGCCCACT-1", "CGCTATTCAATGTATG-1", "CGCTCGACATAATGAT-1",         "CGCTCTCCGTAGATTA-1", "CGCTGTGACGCCGCAC-1", "CGCTTCCACTGAAATC-1",         "CGCTTTCATACCGGTG-1", "CGGAGTTTGAGAGACA-1", "CGGCACTCAAGAAAGT-1",         "CGGCCACGCACAAAGT-1", "CGGGATCAATGTAAGA-1", "CGGGCAGCTAAACCGC-1",         "CGGTGTACTTGATCCC-1", "CGTACCTGATAGGCCT-1", "CGTAGCGAATTGTCAG-1",         "CGTATTAAGAGATCTA-1", "CGTCAGTGCGCACAAG-1", "CGTCTGGAAGGGCCCG-1",         "CGTGTCCCATTCGCGA-1", "CGTTGTTTCAATTCCC-1", "CGTTTAAGCGGAGCAC-1",         "CGTTTCGCTCATTACA-1", "CTAATTCGCACGCGCT-1", "CTAATTTCAACAACAC-1",         "CTACGCACGGAGTACC-1", "CTACTGCCACCTGACC-1", "CTAGCATAGTATAATG-1",         "CTAGTGAAGGACAGGA-1", "CTAGTTGGGCCCGGTA-1", "CTATCGGGTCTCAACA-1",         "CTATGTCACTAGCCCA-1", "CTATGTCTATTGAAAC-1", "CTCAGGACTCACCTGT-1",         "CTCATGGCTCACAATC-1", "CTCATTTGATGGGCGG-1", "CTCCGGCCTAATATGC-1",         "CTCCTAAGTTATGTCT-1", "CTCGAGGTCGAACAGT-1", "CTCGCACCTATATAGT-1",         "CTCGGTCCGTAGCCTG-1", "CTCTCACAATCGATGA-1", "CTCTGCGAAGCAAGCA-1",         "CTCTGGACGCCTGGTG-1", "CTCTGTTTGAGGATTC-1", "CTGAAAGAGATCCGAC-1",         "CTGCACCTGGAACCGC-1", "CTGGAAATGGATGCTT-1", "CTGTATGGTGTAGAAA-1",         "CTGTTCACTGCCTGTG-1", "CTGTTCATCTCACGGG-1", "CTTAACTTCGAAGTAC-1",         "CTTACACGGTATTCCA-1", "CTTACACTGGGAAATA-1", "CTTATGTTGACTACCA-1",         "CTTCATAGCTCAAGAA-1", "CTTCTTACGTCGTATA-1", "CTTGTACTTGTTGACT-1",         "CTTGTTTATGTAGCCA-1", "CTTTAACTTTCAAAGG-1", "CTTTGGCTTTAGTAAA-1",         "GAAACAGCCATGCAGT-1", "GAAACTCTAATGAAGG-1", "GAAAGTGACTAACTGC-1",         "GAAATCGCGCGCAACT-1", "GAAATGGCGGTGTTAG-1", "GAAATTCACATCGCTG-1",         "GAACACACATCAACCA-1", "GAACGACCGAATGATA-1", "GAAGAACGGTGCAGGT-1",         "GAAGCGTGAGGAATTT-1", "GAAGCTTGCTGACCGC-1", "GAAGTGCTGGATAGCT-1",         "GAATCGACATGGTCAC-1", "GAATCGCCGGACACGG-1", "GAATGTTGGGTAATCT-1",         "GAATTATAGTGAAAGG-1", "GAATTTCTCGCTGCAG-1", "GACAACGCAGCTTACG-1",         "GACACAAGGGAAGAAA-1", "GACCAGAGCCCTGTAG-1", "GACGCCTGTTGCAGGG-1",         "GACGTGTAGGGATTAT-1", "GACTAAGATCATGCAC-1", "GACTAAGTAGGCTCAC-1",         "GAGACTGATGGGTAGA-1", "GAGATCTGCTTGGCAT-1", "GAGATCTGTCACTCCG-1",         "GAGCATCATCCCTGGG-1", "GAGCGAGGGAGTACCG-1", "GAGCTCTCGGACCTAA-1",         "GAGGAATGGAGAGGTT-1", "GAGGCTATCAAAGTCG-1", "GAGGGCATCGCGTATC-1",         "GAGGTACATCCATCTT-1", "GAGTACGGGTATACAA-1", "GATAAATCGGTGGATG-1",         "GATATCTCATGCAATA-1", "GATCATTCCAAACATT-1", "GATCCCTTTATACTGC-1",         "GATCGACACTATCTGA-1", "GATCGGTGGCCATAAC-1", "GATGCTACAAGCGCCT-1",         "GATGGCGCACACATTA-1", "GATGTTTGTGCGAGAT-1", "GATTCCCTTGTCGCAG-1",         "GATTCCGCGTTTCCGT-1", "GCAAATATTACGCTTT-1", "GCAAGTGCACAGAGAA-1",         "GCACTAGTCGCGCTAT-1", "GCAGGACTATAGAATA-1", "GCATCCCTAACTTTGA-1",         "GCCCACCAAGGCTGTC-1", "GCCCAGTTGGTATGCC-1", "GCCCGCGCGTTTGACA-1",         "GCCGAAATTCCTACGT-1", "GCCTAGCGATCTGACC-1", "GCCTATTCCGATATAG-1",         "GCCTTCAGCCCTACCG-1", "GCGAAGCCATACCCGT-1", "GCGAGTTCTGCAAAGA-1",         "GCGCTAATTGAATAGA-1", "GCGGGAACCAGGCCCT-1", "GCGGTCCCTAGACGCA-1",         "GCGTCGAAATGTCGGT-1", "GCTAATACCGAATGCC-1", "GCTAGTTTCATTGAGG-1",         "GCTCTAAACCCTGACG-1", "GCTCTATGTTACGTGC-1", "GCTCTCGGGTACCGAA-1",         "GCTGCTCTCCGGACAC-1", "GCTGGCATATTCACCT-1", "GCTTGATGATAATCAG-1",         "GGAGAAGTCATTGGCA-1", "GGAGTGCCGCCCTGGA-1", "GGATTCAGTACGGTGG-1",         "GGCAATAGTCAATGAG-1", "GGCACTCCACTGGGCA-1", "GGCATACAGGTAGCGG-1",         "GGCGGAGTAATATTAG-1", "GGCGGTAGGATCATTG-1", "GGCGTCCTATCCGCTG-1",         "GGCTATTAAGTTGTAT-1", "GGCTCGTGCCACCAGC-1", "GGCTCTGCTCCAACGC-1",         "GGCTGGCTAGCTTAAA-1", "GGGACTGCATAGATAG-1", "GGGAGAACTCACAGTA-1",         "GGGAGTTAATGAGGCG-1", "GGGCGATATGTGTGAA-1", "GGGCGGTCCTATTGTC-1",         "GGGCGTACATTTATAT-1", "GGGCTGCCTAGGGCGA-1", "GGGCTGGTTAGTCGCG-1",         "GGGTATGTATGCACTT-1", "GGGTCACCGTGACGGT-1", "GGGTGTTTCAGCTATG-1",         "GGTAACTATGTATCTG-1", "GGTAGTGCTCGCACCA-1", "GGTATTGCCGAGTTTA-1",         "GGTCGGTAATTAGACA-1", "GGTGAGATGCAGATAA-1", "GGTGCGGATAAGTGGC-1",         "GGTTAGGCTTGGAGAA-1", "GGTTTACAATCTCAAT-1", "GGTTTGAGTGCTGGAA-1",         "GTAAGCGGGCAGTCAG-1", "GTAAGTAGGGTATACC-1", "GTACGAGATTGCGACA-1",         "GTACTAAGATTTGGAG-1", "GTACTGAGGTCGTAAC-1", "GTACTGCATGAAGCGT-1",         "GTACTTGGGCACTTCT-1", "GTAGACGTCGTTACAT-1", "GTATAGGACTCAGTAG-1",         "GTATCAGCTTGGGTTC-1", "GTCAAAGTTTACATAG-1", "GTCACTCTCCAAATCT-1",         "GTCAGAATAGTCTATG-1", "GTCATGCACCTCCGTT-1", "GTCATGGACATGACTA-1",         "GTCCCAACGTAAAGTA-1", "GTCCGGCTGAATTGCG-1", "GTCGGATATCTCAGAC-1",         "GTCGTCAATTATAAGG-1", "GTGAAACGTGCTCCAC-1", "GTGCAACAAATGTGGC-1",         "GTGCACGAAAGTGACT-1", "GTGCGGGTCTCCAAAT-1", "GTGCTCAAGTACTGTC-1",         "GTGGACGTGCTGAGAC-1", "GTGGGCTTAGACACAC-1", "GTTCACAGGAGTCTAG-1",         "GTTCCAGTCTGACCAT-1", "GTTCTTCCCTCGATGT-1", "GTTGCACGGAGTTTCG-1",         "GTTGTCGTGTTAGTTG-1", "GTTTCCTGGAGGGTGA-1", "GTTTGACCAAATCCTA-1",         "GTTTGGCCGCTCAGCG-1", "TAAATGAATCCGTTTC-1", "TAACAAAGGGAGAAGC-1",         "TAACGCTTTGAGAGCG-1", "TAACTATCGAAGGTCC-1", "TAACTCCATGGAGGCT-1",         "TAAGGAACTTGTGGGA-1", "TAAGGCAACATAAGAT-1", "TAATACACAGTAGTAT-1",         "TAATATTGAAATTCGC-1", "TACAAGTCTCGTGCAT-1", "TACCAGCTAGGTTTAA-1",         "TACCTCACGCTTGTAC-1", "TACGAACACGACTTCA-1", "TACGAGAACTTCACGT-1",         "TACGATGTTGATCATC-1", "TACGTGCACTATGCTG-1", "TAGAGCTACGAAGAAC-1",         "TAGAGTCTAAGCGAAC-1", "TAGCTAAGTCCGGGAG-1", "TAGGGTGTTTCAAGAG-1",         "TAGGTGAGCCCTACTC-1", "TAGGTTCGAGTTCGTC-1", "TAGTGCCCTCCAGAGT-1",         "TAGTTTATTCTTGCTT-1", "TATAAATCCACAAGCT-1", "TATAAGTGAGGATAGC-1",         "TATACACGCAAAGTAT-1", "TATCCATATCATGCGA-1", "TATCCTGCATGGGAAT-1",         "TATCGATGATTAAACG-1", "TATGCTCCCTACTTAC-1", "TATGGATGTGCTACGC-1",         "TATGGCCCGGCCTCGC-1", "TATGGGTACGTATCGT-1", "TATTCAATTCTAATCC-1",         "TATTCGTGCCAGAATA-1", "TATTTAGTCTAGATCG-1", "TATTTGTTACCCTTTA-1",         "TCAAACAACCGCGTCG-1", "TCAAACTTAGATTGTT-1", "TCAACACATTGGGTAA-1",         "TCAACCATGTTCGGGC-1", "TCACAGGTTATTGGGC-1", "TCACGCATTGTAGATC-1",         "TCACGGTCATCGCACA-1", "TCAGCAAATGCATCTC-1", "TCAGGGTGTAACGTAA-1",         "TCAGGTTCTTTGAGAA-1", "TCAGTACTGACCCGCG-1", "TCATCACTCGAGCTCG-1",         "TCATCCCAGAGGGTGG-1", "TCCACAATGGTTTACG-1", "TCCAGGCGAGTACGGT-1",         "TCCCAAAGACGAAGGA-1", "TCCCAGCTTTAGTCTG-1", "TCCCAGGCTTAGCTAA-1",         "TCCCGCGTACTCCTGG-1", "TCCCGGGTGTGCTGCT-1", "TCCCGTCAGTCCCGCA-1",         "TCCCTGGCTCGCTGGA-1", "TCCGATAATTGCCATA-1", "TCCGATGACTGAGCTC-1",         "TCCGATGGTGCGACAT-1", "TCCGATTACATTGCCG-1", "TCCTCTACGAGATGGC-1",         "TCCTTCAGTGGTCGAA-1", "TCCTTTCTTACGCTTA-1", "TCGAAATTTAGGACCA-1",         "TCGCATCCCTAAGTGT-1", "TCGCCGGTCGATCCGT-1", "TCGCGTCCAGAAGGTC-1",         "TCGCTCGATATATTCC-1", "TCGCTGGGCGGATTGT-1", "TCGCTGTGCGTAAATC-1",         "TCGGAATGCGCTCTGA-1", "TCGGAGTACATGAGTA-1", "TCGTATAGTGCAATTA-1",         "TCGTCCGCTGGCGTCT-1", "TCTACCGTCCACAAGC-1", "TCTAGCATCTTCGATG-1",         "TCTAGTTATCAGAAGA-1", "TCTATCATGCAGTTAC-1", "TCTATCGGTCGCAACA-1",         "TCTATTACGCTGGCGA-1", "TCTCTAATAGCTGGTA-1", "TCTGAACCGGTCGGCT-1",         "TCTTACAGAGGTACCG-1", "TCTTACGGCATCCGAC-1", "TCTTCGATACCAATAA-1",         "TCTTGATGCGTAGCGA-1", "TCTTGGTAACACCAAA-1", "TGAAACTTATGCAAGC-1",         "TGACCCACGTTAGACA-1", "TGAGAATGCTTTACCG-1", "TGATCGGTTTGACCCT-1",         "TGATCTCCGGCGCCAG-1", "TGATTCGTCTATCACT-1", "TGATTTCCTCCTGACG-1",         "TGCAAGAATGACGTAA-1", "TGCAGGATCGGCAAAG-1", "TGCATGGATCGGATCT-1",         "TGCCACCTGGCGAAAC-1", "TGCCTGATCAAACGAT-1", "TGCGCAAAGCATTTGG-1",         "TGCGCGATTAACGGAG-1", "TGCGGAGTAAAGGTGC-1", "TGCGGCATAGTTCAAC-1",         "TGCGGTGAAATTTCAT-1", "TGCTGGTTGGACAATT-1", "TGGAAGACGAACACCA-1",         "TGGAAGGATAAAGATG-1", "TGGAGTGATGCGATGA-1", "TGGCCAAACTGAAGTA-1",         "TGGCCGTATATTGACC-1", "TGGCTTTGGGTAGACA-1", "TGGGAAATGCCTTTCC-1",         "TGGGCACGTTCTATGG-1", "TGGGCCACAAGAGCGC-1", "TGGTTCGTAGCAAAGG-1",         "TGTAGTGATCTATAAT-1", "TGTCCCGACATAGCAC-1", "TGTCCTAAGTCACCGC-1",         "TGTCTACAGTTTCTGT-1", "TGTGACTACGCCAGTC-1", "TGTGTCGCGAGTTGCA-1",         "TGTTCTTCCATTGACT-1", "TGTTTCGGTACTTCTC-1", "TTAACCAACCCTCCCT-1",         "TTAAGCGCCTGACCCA-1", "TTAATCAGTACGTCAG-1", "TTAATGTAGACCAGGT-1",         "TTAATTTCAGACGCGG-1", "TTACAACTACGCATCC-1", "TTACATCGTGGCCTGG-1",         "TTACCATTGATTACCC-1", "TTAGCAACATGGATGT-1", "TTATATTTGGCAATCC-1",         "TTATCCAATCGAACTC-1", "TTATCTGTATCATAAC-1", "TTATGACAAACTGGAT-1",         "TTATTAGGGAAGCATC-1", "TTCAAAGTCTCTAGCC-1", "TTCAACGACCCGACCG-1",         "TTCAAGCCGAGCTGAG-1", "TTCATGGCGCAACAGG-1", "TTCCTCGAGGGTGTCT-1",         "TTCGACGGGAAGGGCG-1", "TTCGCACTCGCGTGCT-1", "TTCGTACTCCAGAACG-1",         "TTCTACTTGCGAGGGC-1", "TTCTAGGCCAATTGTG-1", "TTCTTAGTGAACGGTG-1",         "TTCTTAGTGGCTCAGA-1", "TTCTTGTAACCTAATG-1", "TTGAAGAATTCCCAGG-1",         "TTGAATATGGACTTTC-1", "TTGATCTAACTTTGTC-1", "TTGATTATGCAGATGA-1",         "TTGCACGGAGCAGCAC-1", "TTGCTCCCATACCGGA-1", "TTGCTGAAGGAACCAC-1",         "TTGCTGATCATGTTCG-1", "TTGGATTGGGTACCAC-1", "TTGGCTCGCATGAGAC-1",         "TTGGGACACTGCCCGC-1", "TTGGGCGGCGGTTGCC-1", "TTGTAATCCGTACTCG-1",         "TTGTATCACACAGAAT-1", "TTGTCGTTCAGTTACC-1", "TTGTGGCCCTGACAGT-1",         "TTGTTCAGTGTGCTAC-1"), in_tissue = c(1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,         1L, 1L, 1L, 1L), nr_feats = c(227L, 283L, 248L, 222L,         313L, 338L, 345L, 247L, 211L, 237L, 254L, 264L, 311L,         343L, 429L, 265L, 252L, 273L, 334L, 413L, 195L, 375L,         382L, 256L, 165L, 264L, 322L, 220L, 253L, 156L, 324L,         270L, 276L, 335L, 309L, 296L, 238L, 156L, 426L, 238L,         223L, 345L, 380L, 245L, 306L, 206L, 247L, 220L, 343L,         338L, 441L, 247L, 239L, 276L, 245L, 402L, 254L, 274L,         304L, 147L, 283L, 271L, 216L, 237L, 373L, 216L, 201L,         257L, 332L, 208L, 367L, 336L, 239L, 314L, 278L, 311L,         261L, 176L, 302L, 285L, 256L, 299L, 237L, 287L, 246L,         320L, 404L, 364L, 207L, 332L, 255L, 186L, 316L, 253L,         344L, 321L, 318L, 317L, 239L, 251L, 379L, 307L, 296L,         270L, 288L, 318L, 272L, 319L, 335L, 305L, 388L, 292L,         188L, 313L, 274L, 212L, 270L, 226L, 236L, 393L, 210L,         199L, 281L, 284L, 302L, 307L, 180L, 300L, 318L, 226L,         219L, 219L, 293L, 272L, 281L, 230L, 267L, 230L, 247L,         308L, 233L, 247L, 214L, 214L, 305L, 279L, 279L, 278L,         300L, 215L, 258L, 274L, 220L, 262L, 225L, 150L, 154L,         332L, 308L, 400L, 200L, 173L, 335L, 356L, 331L, 256L,         161L, 274L, 328L, 303L, 386L, 253L, 267L, 284L, 186L,         294L, 285L, 309L, 426L, 280L, 298L, 194L, 228L, 309L,         296L, 135L, 240L, 215L, 250L, 367L, 362L, 305L, 318L,         220L, 245L, 255L, 289L, 317L, 214L, 246L, 308L, 343L,         261L, 332L, 342L, 272L, 300L, 309L, 321L, 232L, 374L,         230L, 426L, 222L, 194L, 308L, 372L, 236L, 363L, 209L,         305L, 255L, 285L, 270L, 288L, 234L, 312L, 206L, 361L,         322L, 207L, 317L, 265L, 338L, 189L, 272L, 300L, 362L,         299L, 277L, 331L, 251L, 199L, 232L, 242L, 319L, 342L,         162L, 303L, 294L, 299L, 204L, 297L, 359L, 235L, 194L,         187L, 252L, 324L, 219L, 265L, 283L, 343L, 341L, 231L,         227L, 314L, 195L, 305L, 322L, 358L, 336L, 172L, 285L,         346L, 260L, 288L, 238L, 263L, 244L, 223L, 335L, 325L,         230L, 268L, 323L, 267L, 308L, 256L, 277L, 309L, 325L,         267L, 271L, 182L, 334L, 169L, 272L, 270L, 234L, 342L,         248L, 164L, 94L, 342L, 243L, 210L, 273L, 160L, 277L,         208L, 235L, 261L, 285L, 323L, 288L, 253L, 314L, 313L,         388L, 279L, 222L, 270L, 315L, 255L, 272L, 327L, 306L,         161L, 248L, 407L, 219L, 209L, 273L, 219L, 207L, 197L,         225L, 361L, 309L, 152L, 288L, 368L, 281L, 239L, 347L,         294L, 287L, 164L, 223L, 288L, 362L, 194L, 286L, 347L,         345L, 294L, 279L, 316L, 286L, 243L, 403L, 359L, 280L,         315L, 302L, 143L, 202L, 325L, 232L, 204L, 287L, 261L,         340L, 188L, 235L, 300L, 313L, 230L, 244L, 276L, 222L,         194L, 350L, 280L, 185L, 235L, 262L, 245L, 338L, 259L,         239L, 361L, 336L, 170L, 306L, 214L, 231L, 279L, 323L,         214L, 205L, 291L, 267L, 153L, 242L, 244L, 422L, 307L,         284L, 253L, 179L, 289L, 239L, 280L, 269L, 329L, 353L,         284L, 294L, 188L, 215L, 331L, 337L, 302L, 185L, 261L,         340L, 117L, 221L, 168L, 215L, 215L, 205L, 289L, 334L,         288L, 197L, 268L, 355L, 309L, 245L, 321L, 237L, 303L,         294L, 250L, 263L, 302L, 179L, 403L, 246L, 255L, 218L,         179L, 356L, 163L, 232L, 369L, 278L, 204L, 369L, 319L,         227L, 357L, 266L, 224L, 295L, 151L, 314L, 316L, 368L,         234L, 256L, 233L, 308L, 319L, 163L, 174L, 216L, 370L,         355L, 226L, 90L, 252L, 264L, 282L, 247L, 364L, 233L,         445L, 217L, 318L, 261L, 386L, 336L, 303L, 256L, 197L,         258L, 282L, 318L, 207L, 237L, 321L, 294L, 171L, 218L,         302L, 367L, 234L, 338L, 256L, 263L, 330L, 346L, 238L,         164L, 303L, 303L, 383L, 210L, 234L, 195L, 234L, 257L,         230L, 267L, 121L, 165L, 164L, 233L, 314L, 310L, 246L,         344L, 286L, 218L, 146L, 171L, 310L, 259L, 225L, 277L,         245L, 212L, 348L, 309L, 373L, 241L, 215L, 398L, 321L,         288L, 349L, 375L, 326L, 234L, 374L, 242L, 283L, 156L,         342L, 379L, 319L, 429L, 171L, 267L, 315L, 278L, 297L,         192L, 254L, 267L, 231L, 253L, 383L, 289L, 249L, 265L,         367L, 277L, 294L, 330L, 306L, 218L, 185L, 193L, 266L,         186L, 263L, 266L, 207L, 332L, 384L, 190L, 281L, 303L,         263L, 405L, 389L, 297L, 153L, 126L, 287L, 359L, 103L,         289L, 380L, 272L, 178L, 313L, 331L, 355L, 227L, 253L,         188L, 364L, 335L, 315L, 240L, 220L, 204L, 237L), perc_feats = c(35.8044164037855,         44.6372239747634, 39.1167192429022, 35.0157728706625,         49.3690851735016, 53.3123028391167, 54.416403785489,         38.9589905362776, 33.2807570977918, 37.3817034700315,         40.0630914826498, 41.6403785488959, 49.0536277602524,         54.1009463722397, 67.6656151419558, 41.7981072555205,         39.7476340694006, 43.0599369085174, 52.6813880126183,         65.1419558359621, 30.7570977917981, 59.1482649842271,         60.2523659305994, 40.3785488958991, 26.0252365930599,         41.6403785488959, 50.788643533123, 34.7003154574132,         39.9053627760252, 24.6056782334385, 51.1041009463722,         42.5867507886435, 43.5331230283912, 52.8391167192429,         48.7381703470032, 46.6876971608833, 37.5394321766561,         24.6056782334385, 67.192429022082, 37.5394321766561,         35.1735015772871, 54.416403785489, 59.9369085173502,         38.6435331230284, 48.2649842271293, 32.4921135646688,         38.9589905362776, 34.7003154574132, 54.1009463722397,         53.3123028391167, 69.5583596214511, 38.9589905362776,         37.6971608832808, 43.5331230283912, 38.6435331230284,         63.4069400630915, 40.0630914826498, 43.217665615142,         47.9495268138801, 23.186119873817, 44.6372239747634,         42.7444794952681, 34.0694006309148, 37.3817034700315,         58.8328075709779, 34.0694006309148, 31.7034700315457,         40.5362776025237, 52.3659305993691, 32.807570977918,         57.8864353312303, 52.9968454258675, 37.6971608832808,         49.5268138801262, 43.8485804416404, 49.0536277602524,         41.1671924290221, 27.7602523659306, 47.6340694006309,         44.9526813880126, 40.3785488958991, 47.1608832807571,         37.3817034700315, 45.2681388012618, 38.801261829653,         50.4731861198738, 63.7223974763407, 57.4132492113565,         32.6498422712934, 52.3659305993691, 40.2208201892744,         29.3375394321767, 49.8422712933754, 39.9053627760252,         54.2586750788643, 50.6309148264984, 50.1577287066246,         50, 37.6971608832808, 39.589905362776, 59.7791798107255,         48.4227129337539, 46.6876971608833, 42.5867507886435,         45.4258675078864, 50.1577287066246, 42.9022082018927,         50.3154574132492, 52.8391167192429, 48.1072555205047,         61.198738170347, 46.0567823343849, 29.6529968454259,         49.3690851735016, 43.217665615142, 33.4384858044164,         42.5867507886435, 35.6466876971609, 37.2239747634069,         61.98738170347, 33.1230283911672, 31.3880126182965, 44.3217665615142,         44.794952681388, 47.6340694006309, 48.4227129337539,         28.391167192429, 47.3186119873817, 50.1577287066246,         35.6466876971609, 34.5425867507886, 34.5425867507886,         46.2145110410095, 42.9022082018927, 44.3217665615142,         36.2776025236593, 42.1135646687697, 36.2776025236593,         38.9589905362776, 48.5804416403785, 36.7507886435331,         38.9589905362776, 33.7539432176656, 33.7539432176656,         48.1072555205047, 44.006309148265, 44.006309148265, 43.8485804416404,         47.3186119873817, 33.9116719242902, 40.6940063091483,         43.217665615142, 34.7003154574132, 41.3249211356467,         35.4889589905363, 23.6593059936909, 24.2902208201893,         52.3659305993691, 48.5804416403785, 63.0914826498423,         31.5457413249211, 27.2870662460568, 52.8391167192429,         56.1514195583596, 52.2082018927445, 40.3785488958991,         25.3943217665615, 43.217665615142, 51.7350157728707,         47.7917981072555, 60.8832807570978, 39.9053627760252,         42.1135646687697, 44.794952681388, 29.3375394321767,         46.3722397476341, 44.9526813880126, 48.7381703470032,         67.192429022082, 44.1640378548896, 47.0031545741325,         30.5993690851735, 35.9621451104101, 48.7381703470032,         46.6876971608833, 21.2933753943218, 37.8548895899054,         33.9116719242902, 39.4321766561514, 57.8864353312303,         57.0977917981073, 48.1072555205047, 50.1577287066246,         34.7003154574132, 38.6435331230284, 40.2208201892744,         45.583596214511, 50, 33.7539432176656, 38.801261829653,         48.5804416403785, 54.1009463722397, 41.1671924290221,         52.3659305993691, 53.9432176656151, 42.9022082018927,         47.3186119873817, 48.7381703470032, 50.6309148264984,         36.5930599369085, 58.9905362776025, 36.2776025236593,         67.192429022082, 35.0157728706625, 30.5993690851735,         48.5804416403785, 58.6750788643533, 37.2239747634069,         57.2555205047319, 32.9652996845426, 48.1072555205047,         40.2208201892744, 44.9526813880126, 42.5867507886435,         45.4258675078864, 36.9085173501577, 49.211356466877,         32.4921135646688, 56.9400630914826, 50.788643533123,         32.6498422712934, 50, 41.7981072555205, 53.3123028391167,         29.8107255520505, 42.9022082018927, 47.3186119873817,         57.0977917981073, 47.1608832807571, 43.6908517350158,         52.2082018927445, 39.589905362776, 31.3880126182965,         36.5930599369085, 38.1703470031546, 50.3154574132492,         53.9432176656151, 25.5520504731861, 47.7917981072555,         46.3722397476341, 47.1608832807571, 32.1766561514196,         46.8454258675079, 56.6246056782334, 37.0662460567823,         30.5993690851735, 29.4952681388013, 39.7476340694006,         51.1041009463722, 34.5425867507886, 41.7981072555205,         44.6372239747634, 54.1009463722397, 53.7854889589905,         36.4353312302839, 35.8044164037855, 49.5268138801262,         30.7570977917981, 48.1072555205047, 50.788643533123,         56.4668769716088, 52.9968454258675, 27.1293375394322,         44.9526813880126, 54.5741324921136, 41.0094637223975,         45.4258675078864, 37.5394321766561, 41.4826498422713,         38.4858044164038, 35.1735015772871, 52.8391167192429,         51.2618296529969, 36.2776025236593, 42.2712933753943,         50.9463722397476, 42.1135646687697, 48.5804416403785,         40.3785488958991, 43.6908517350158, 48.7381703470032,         51.2618296529969, 42.1135646687697, 42.7444794952681,         28.7066246056782, 52.6813880126183, 26.6561514195584,         42.9022082018927, 42.5867507886435, 36.9085173501577,         53.9432176656151, 39.1167192429022, 25.8675078864353,         14.8264984227129, 53.9432176656151, 38.3280757097792,         33.1230283911672, 43.0599369085174, 25.2365930599369,         43.6908517350158, 32.807570977918, 37.0662460567823,         41.1671924290221, 44.9526813880126, 50.9463722397476,         45.4258675078864, 39.9053627760252, 49.5268138801262,         49.3690851735016, 61.198738170347, 44.006309148265, 35.0157728706625,         42.5867507886435, 49.6845425867508, 40.2208201892744,         42.9022082018927, 51.5772870662461, 48.2649842271293,         25.3943217665615, 39.1167192429022, 64.1955835962145,         34.5425867507886, 32.9652996845426, 43.0599369085174,         34.5425867507886, 32.6498422712934, 31.0725552050473,         35.4889589905363, 56.9400630914826, 48.7381703470032,         23.9747634069401, 45.4258675078864, 58.0441640378549,         44.3217665615142, 37.6971608832808, 54.7318611987382,         46.3722397476341, 45.2681388012618, 25.8675078864353,         35.1735015772871, 45.4258675078864, 57.0977917981073,         30.5993690851735, 45.1104100946372, 54.7318611987382,         54.416403785489, 46.3722397476341, 44.006309148265, 49.8422712933754,         45.1104100946372, 38.3280757097792, 63.5646687697161,         56.6246056782334, 44.1640378548896, 49.6845425867508,         47.6340694006309, 22.5552050473186, 31.8611987381703,         51.2618296529969, 36.5930599369085, 32.1766561514196,         45.2681388012618, 41.1671924290221, 53.6277602523659,         29.6529968454259, 37.0662460567823, 47.3186119873817,         49.3690851735016, 36.2776025236593, 38.4858044164038,         43.5331230283912, 35.0157728706625, 30.5993690851735,         55.205047318612, 44.1640378548896, 29.1798107255521,         37.0662460567823, 41.3249211356467, 38.6435331230284,         53.3123028391167, 40.8517350157729, 37.6971608832808,         56.9400630914826, 52.9968454258675, 26.813880126183,         48.2649842271293, 33.7539432176656, 36.4353312302839,         44.006309148265, 50.9463722397476, 33.7539432176656,         32.3343848580442, 45.8990536277603, 42.1135646687697,         24.1324921135647, 38.1703470031546, 38.4858044164038,         66.5615141955836, 48.4227129337539, 44.794952681388,         39.9053627760252, 28.2334384858044, 45.583596214511,         37.6971608832808, 44.1640378548896, 42.4290220820189,         51.8927444794953, 55.6782334384858, 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      791.360787896315, 1091.46995904337, 874.171641770601,         1136.750705269, 1176.78271533588, 759.175711977634, 833.015825765764,         974.451049760855, 1120.49398290782, 1230.11818704412,         1006.72358137007, 534.174213658673, 1069.5524682778,         1074.3703653083, 1025.84950615133, 921.826426331041,         1213.3739825443, 1007.63860950274, 1263.08154688765,         976.639081769557, 1003.64998144913, 1063.35173304575,         1195.25184747407, 1226.27460532745, 1150.2126685881,         1075.47157840457, 868.840285334027, 1060.18544407636,         1153.62603990586, 1153.76666784712, 856.927922199376,         997.528561347136, 1107.92272305668, 1137.26823747713,         844.941376479426, 956.236018798489, 1175.67768894008,         1095.70076163552, 1013.4656625271, 1194.38802909718,         1088.99443345778, 936.67022980206, 1176.93543473413,         1177.74723574121, 1021.64293042626, 802.713974099176,         1147.67871582472, 1131.01192302099, 1226.96256838525,         870.460785892088, 1022.22870709406, 896.795271403771,         996.2102724541, 1023.7651674657, 999.400651419049, 1077.23439007785,         609.822058312369, 799.892621773862, 803.519385118485,         992.90620935012, 1113.38678885843, 1148.7760839154, 1065.85921405778,         1084.6477018085, 979.82487122063, 992.516822490875, 758.82854410995,         837.209676696007, 1157.32310266157, 1050.26008916, 948.698388110398,         1101.76672867066, 1043.08842461029, 949.371092782475,         1072.44013370125, 1052.06463567415, 1116.35159775393,         1031.34610678917, 963.010326339346, 1072.16784833961,         990.116487658682, 1001.05172344948, 1234.29864311464,         1195.85293197176, 1024.11653330572, 1011.06024499406,         1221.37676532543, 1013.3624274076, 1123.15561440324,         778.323254312245, 1126.39926949168, 1272.46693250729,         1216.42004797225, 1361.8208304174, 841.747847838327,         1102.88307914987, 977.868009032042, 1122.16975079534,         1130.20864817178, 836.297449148413, 1050.90941494478,         1003.87747610452, 990.027544297921, 1049.97665609377,         1075.56023893662, 1075.64451501875, 1051.07682906703,         919.948881534829, 1183.25610320381, 1106.73404586847,         1120.56235656135, 1003.45069163949, 1097.55688659503,         822.603002712797, 879.414816012222, 884.498409861202,         1098.43925978458, 878.590133463639, 1027.29393858503,         1110.18874377088, 936.256932560715, 1190.07846348807,         916.592855409712, 894.260357637752, 1103.17140094924,         1101.23095357521, 1057.78357579323, 1226.20070515932,         1342.08106369467, 1149.18357250559, 789.595316615116,         525.519608557264, 942.686566618832, 1189.9151119911,         592.829149614415, 1119.45986306101, 912.305143466939,         940.494192466699, 805.428913159954, 1206.77802251838,         1083.72890979688, 1088.26723655449, 985.389052458918,         879.756775065605, 897.554063829254, 1115.16961458823,         1150.23011882017, 1184.01781830254, 999.641936650241,         994.664812118689, 930.548850034589, 1034.88927889182),         leiden_clus = c(1, 2, 4, 4, 6, 2, 6, 5, 1, 5, 2, 5, 5,         3, 3, 2, 2, 5, 6, 7, 5, 4, 3, 4, 1, 4, 2, 1, 1, 1, 2,         1, 3, 6, 7, 2, 1, 1, 3, 1, 1, 3, 3, 4, 2, 1, 4, 1, 6,         2, 7, 5, 1, 5, 2, 3, 2, 3, 2, 1, 4, 1, 5, 5, 6, 4, 1,         5, 3, 1, 4, 2, 1, 4, 5, 5, 1, 1, 4, 1, 2, 5, 1, 2, 2,         3, 6, 5, 1, 3, 6, 1, 2, 2, 4, 2, 5, 2, 3, 5, 3, 3, 4,         2, 4, 5, 5, 4, 3, 4, 3, 5, 1, 6, 2, 1, 4, 1, 5, 3, 1,         1, 2, 5, 2, 3, 1, 5, 3, 1, 1, 3, 5, 5, 3, 1, 1, 5, 1,         2, 1, 1, 1, 3, 2, 4, 6, 2, 2, 4, 2, 4, 2, 2, 1, 1, 1,         4, 5, 6, 1, 1, 6, 3, 2, 3, 1, 2, 2, 6, 6, 4, 5, 2, 1,         4, 3, 3, 3, 4, 5, 6, 1, 4, 5, 1, 2, 5, 2, 6, 2, 2, 2,         1, 5, 3, 1, 4, 1, 1, 5, 4, 5, 2, 3, 2, 5, 5, 4, 1, 4,         4, 5, 1, 1, 3, 6, 5, 2, 3, 2, 1, 5, 2, 2, 5, 3, 2, 3,         3, 4, 2, 2, 5, 4, 2, 6, 3, 4, 3, 2, 2, 4, 1, 2, 2, 3,         1, 1, 6, 7, 1, 2, 3, 5, 1, 1, 4, 3, 1, 5, 6, 2, 4, 1,         4, 5, 1, 2, 4, 2, 2, 1, 4, 2, 4, 7, 1, 4, 1, 5, 6, 3,         5, 3, 2, 5, 2, 3, 1, 2, 3, 1, 3, 1, 2, 1, 2, 2, 5, 4,         3, 1, 1, 2, 4, 1, 2, 1, 2, 1, 5, 3, 4, 2, 2, 5, 2, 4,         2, 1, 1, 5, 6, 4, 2, 3, 2, 1, 5, 7, 1, 1, 4, 2, 7, 1,         1, 3, 6, 1, 2, 2, 5, 1, 6, 2, 2, 1, 1, 2, 4, 1, 3, 3,         3, 5, 3, 3, 2, 4, 3, 2, 4, 3, 2, 1, 1, 4, 1, 1, 1, 3,         5, 5, 1, 2, 2, 1, 3, 1, 3, 1, 3, 4, 1, 3, 1, 3, 3, 4,         4, 4, 3, 4, 4, 1, 1, 5, 6, 3, 5, 3, 5, 1, 1, 4, 7, 4,         2, 2, 5, 4, 2, 3, 3, 6, 6, 2, 3, 3, 1, 3, 2, 2, 1, 5,         3, 1, 5, 1, 4, 1, 1, 5, 3, 4, 2, 2, 2, 2, 1, 4, 3, 4,         4, 1, 5, 3, 1, 3, 3, 2, 3, 1, 7, 1, 5, 3, 1, 1, 3, 6,         2, 6, 4, 4, 4, 1, 2, 6, 3, 1, 6, 5, 4, 2, 1, 1, 1, 3,         2, 1, 1, 3, 6, 4, 5, 6, 1, 3, 5, 3, 2, 3, 4, 4, 3, 1,         1, 6, 3, 5, 2, 4, 4, 1, 4, 4, 3, 4, 2, 6, 5, 2, 3, 4,         1, 2, 3, 4, 5, 1, 6, 1, 5, 1, 6, 1, 2, 1, 1, 3, 4, 1,         3, 5, 1, 1, 1, 7, 3, 1, 1, 2, 4, 3, 3, 6, 4, 1, 3, 5,         5, 2, 5, 3, 1, 6, 2, 2, 1, 5, 6, 4, 6, 1, 1, 3, 2, 2,         1, 4, 2, 4, 2, 5, 3, 4, 1, 3, 4, 2, 3, 2, 1, 1, 4, 5,         1, 5, 1, 1, 2, 6, 1, 2, 2, 5, 3, 3, 6, 1, 1, 3, 5, 1,         4, 6, 4, 1, 3, 5, 3, 4, 1, 1, 3, 6, 4, 2, 1, 5, 1), custom_leiden = c(1,         3, 2, 2, 2, 3, 2, 4, 1, 1, 3, 4, 4, 5, 6, 4, 3, 1, 2,         1, 4, 2, 6, 2, 1, 2, 3, 1, 1, 1, 3, 1, 1, 2, 1, 3, 1,         1, 6, 1, 1, 5, 5, 2, 3, 1, 2, 1, 2, 3, 1, 4, 1, 4, 3,         6, 3, 1, 3, 1, 2, 1, 4, 4, 7, 2, 1, 1, 5, 1, 2, 3, 1,         2, 4, 4, 1, 1, 2, 1, 3, 1, 1, 3, 3, 5, 2, 4, 1, 5, 2,         1, 3, 3, 2, 3, 4, 3, 6, 4, 6, 5, 2, 3, 2, 7, 4, 2, 5,         2, 8, 4, 1, 2, 3, 1, 2, 1, 1, 6, 1, 1, 3, 4, 4, 6, 1,         4, 6, 1, 1, 1, 4, 4, 5, 1, 1, 4, 1, 3, 1, 1, 1, 6, 3,         2, 2, 3, 3, 2, 3, 2, 3, 3, 1, 1, 1, 2, 4, 7, 1, 1, 2,         5, 3, 5, 1, 3, 3, 2, 7, 2, 4, 3, 1, 2, 5, 1, 6, 2, 1,         2, 1, 2, 4, 1, 3, 4, 3, 7, 3, 3, 1, 1, 4, 8, 1, 2, 1,         1, 4, 2, 1, 3, 8, 3, 4, 4, 2, 1, 2, 2, 3, 1, 1, 5, 2,         4, 3, 8, 3, 1, 4, 3, 3, 4, 1, 3, 1, 5, 2, 3, 3, 4, 2,         3, 7, 8, 2, 1, 3, 3, 2, 1, 3, 3, 1, 1, 1, 2, 1, 1, 3,         8, 1, 1, 1, 2, 8, 1, 4, 2, 3, 2, 1, 2, 4, 1, 3, 2, 3,         3, 1, 2, 3, 2, 1, 1, 2, 1, 4, 2, 1, 4, 1, 3, 4, 3, 5,         1, 3, 8, 1, 5, 1, 3, 1, 3, 4, 1, 2, 5, 1, 1, 3, 2, 1,         3, 1, 3, 1, 4, 1, 2, 3, 3, 1, 3, 2, 3, 1, 1, 4, 2, 2,         3, 6, 3, 1, 4, 1, 1, 1, 2, 3, 1, 1, 1, 1, 2, 1, 3, 3,         4, 1, 2, 3, 3, 1, 1, 3, 2, 1, 6, 1, 5, 1, 5, 1, 3, 2,         6, 3, 2, 5, 3, 1, 1, 2, 1, 1, 1, 1, 4, 4, 1, 3, 3, 1,         5, 1, 6, 1, 1, 2, 1, 6, 1, 5, 1, 2, 2, 2, 1, 2, 2, 1,         1, 3, 2, 1, 4, 1, 4, 1, 1, 2, 1, 2, 3, 3, 4, 2, 3, 5,         5, 2, 7, 3, 1, 6, 1, 8, 3, 3, 1, 3, 5, 1, 4, 1, 2, 1,         1, 4, 1, 2, 3, 3, 3, 3, 1, 2, 5, 2, 2, 1, 4, 6, 1, 6,         1, 3, 1, 1, 1, 1, 4, 5, 3, 1, 5, 2, 3, 1, 2, 2, 2, 1,         3, 2, 1, 1, 2, 4, 2, 3, 1, 1, 1, 5, 3, 1, 1, 6, 2, 2,         4, 2, 1, 6, 1, 1, 3, 6, 2, 2, 1, 1, 1, 2, 6, 4, 3, 2,         2, 1, 2, 2, 1, 2, 4, 2, 4, 3, 6, 2, 1, 3, 1, 2, 4, 1,         2, 1, 4, 1, 2, 4, 3, 1, 1, 6, 2, 1, 5, 4, 1, 1, 1, 1,         1, 1, 1, 3, 2, 5, 8, 2, 2, 1, 1, 4, 4, 3, 4, 1, 1, 7,         3, 3, 1, 4, 4, 2, 7, 1, 1, 5, 3, 3, 1, 2, 3, 2, 3, 4,         6, 2, 1, 5, 2, 3, 1, 3, 1, 1, 2, 1, 1, 3, 1, 1, 3, 7,         1, 3, 3, 1, 6, 8, 2, 1, 1, 5, 4, 1, 2, 4, 2, 1, 1, 4,         5, 2, 3, 1, 1, 7, 2, 3, 1, 1, 1), sdimx = c(5477L, 5959L,         4720L, 5202L, 4101L, 5821L, 3344L, 3275L, 3895L, 6028L,         5615L, 4858L, 6440L, 5684L, 3964L, 3069L, 5752L, 5752L,         3069L, 3069L, 6234L, 4514L, 3826L, 4376L, 4445L, 3344L,         4445L, 4445L, 5271L, 3619L, 5821L, 6165L, 3275L, 3757L,         5064L, 5615L, 4652L, 3895L, 4170L, 6097L, 6096L, 5546L,         4583L, 4927L, 5684L, 5752L, 3276L, 5546L, 5408L, 6234L,         5477L, 3069L, 5821L, 5546L, 5890L, 4032L, 6303L, 5959L,         6028L, 3895L, 4996L, 5615L, 3344L, 3413L, 6372L, 4583L,         5477L, 6234L, 3138L, 5064L, 4376L, 5615L, 3138L, 4239L,         3619L, 6372L, 4996L, 5684L, 3620L, 4789L, 5684L, 5271L,         4996L, 3757L, 6303L, 3826L, 3826L, 4996L, 3276L, 4307L,         5684L, 5546L, 4032L, 6440L, 3344L, 6303L, 5340L, 4720L,         3482L, 3138L, 3895L, 5752L, 4652L, 5477L, 4652L, 6372L,         3275L, 3207L, 5408L, 4308L, 4514L, 6096L, 5615L, 5409L,         5271L, 3413L, 4996L, 5684L, 5821L, 3757L, 5408L, 5133L,         6165L, 6440L, 5133L, 4239L, 4376L, 5202L, 3620L, 4927L,         4308L, 5684L, 6372L, 6097L, 3207L, 5408L, 5133L, 3207L,         5752L, 5752L, 4239L, 4583L, 4858L, 3895L, 4720L, 4583L,         4170L, 4789L, 4789L, 3826L, 6096L, 3964L, 6372L, 5821L,         4652L, 3826L, 4376L, 3826L, 5752L, 6303L, 5684L, 3069L,         5271L, 5340L, 5408L, 4170L, 5271L, 6165L, 6028L, 3207L,         6165L, 4170L, 4720L, 6096L, 4170L, 4514L, 3344L, 6028L,         4376L, 5271L, 4101L, 3138L, 3757L, 4720L, 3619L, 4308L,         5959L, 4239L, 4170L, 5959L, 5546L, 5340L, 5133L, 5752L,         5684L, 4789L, 4514L, 3757L, 5477L, 6097L, 4514L, 4101L,         4376L, 6372L, 4858L, 6440L, 5477L, 3826L, 4858L, 4170L,         4101L, 3895L, 6303L, 4032L, 4720L, 4239L, 3895L, 3069L,         4995L, 3413L, 5064L, 4789L, 6441L, 3551L, 4514L, 3413L,         4583L, 6165L, 5959L, 3619L, 3482L, 6096L, 6303L, 6234L,         3688L, 6372L, 6096L, 4652L, 4170L, 5821L, 6234L, 6028L,         3620L, 6234L, 4376L, 5821L, 6096L, 3757L, 3482L, 4239L,         3138L, 5133L, 6372L, 4720L, 3688L, 3344L, 4308L, 3757L,         4445L, 4101L, 4651L, 3551L, 3138L, 5271L, 5271L, 5064L,         3344L, 5890L, 6096L, 4927L, 4583L, 5477L, 3964L, 3964L,         5271L, 4583L, 3551L, 3069L, 5133L, 5546L, 5753L, 3826L,         5890L, 5959L, 5752L, 4995L, 3275L, 5546L, 5477L, 5271L,         3275L, 5271L, 5890L, 4652L, 6028L, 4651L, 5477L, 6165L,         5959L, 4583L, 4858L, 3413L, 5064L, 3551L, 5546L, 4308L,         4514L, 3069L, 3757L, 5340L, 4720L, 3138L, 5821L, 3964L,         5408L, 6234L, 3344L, 5890L, 4789L, 4583L, 4652L, 5546L,         3963L, 5340L, 3620L, 5408L, 4101L, 4032L, 5959L, 5890L,         3276L, 4927L, 6165L, 4445L, 3344L, 3413L, 4858L, 4170L,         5064L, 4239L, 6303L, 3963L, 5202L, 3482L, 3344L, 3069L,         3482L, 5890L, 4170L, 4032L, 5202L, 5064L, 5340L, 4445L,         5890L, 4720L, 3207L, 3275L, 5821L, 6440L, 4032L, 4101L,         4170L, 3757L, 4101L, 3826L, 3826L, 3963L, 4308L, 4101L,         3275L, 4651L, 5408L, 5546L, 6028L, 4514L, 4307L, 5684L,         4445L, 3757L, 5202L, 3964L, 5202L, 5546L, 3344L, 3688L,         4032L, 4858L, 3482L, 6028L, 4376L, 3413L, 4376L, 5959L,         3482L, 4032L, 3826L, 6165L, 3207L, 5340L, 5615L, 6372L,         5202L, 3138L, 4927L, 5959L, 4720L, 3138L, 4445L, 5890L,         4239L, 6165L, 4858L, 3688L, 3688L, 4376L, 3688L, 6234L,         4101L, 5546L, 3688L, 5133L, 4996L, 4445L, 3895L, 3482L,         3895L, 5202L, 3551L, 3207L, 3344L, 3413L, 5408L, 5477L,         6234L, 4789L, 3688L, 4307L, 3757L, 5477L, 6096L, 5064L,         4789L, 3895L, 3895L, 3551L, 4858L, 4720L, 4514L, 4445L,         4583L, 5202L, 3413L, 3207L, 3619L, 3207L, 3551L, 3069L,         3963L, 6096L, 5615L, 4445L, 3069L, 5684L, 5064L, 4858L,         3895L, 3620L, 3482L, 4858L, 4996L, 5133L, 4927L, 3482L,         5821L, 4789L, 5133L, 4239L, 3895L, 3688L, 4789L, 4927L,         4583L, 5408L, 4927L, 3276L, 5202L, 6303L, 5615L, 5202L,         4376L, 5340L, 5684L, 3619L, 4720L, 4514L, 4583L, 4308L,         6234L, 6165L, 4101L, 3551L, 3207L, 6028L, 3688L, 5133L,         5340L, 5064L, 4514L, 5959L, 3551L, 6372L, 3069L, 5615L,         6440L, 4858L, 3413L, 3413L, 5959L, 5477L, 4308L, 3344L,         5408L, 3207L, 5546L, 6303L, 4032L, 3138L, 6303L, 5064L,         3964L, 5821L, 4170L, 4927L, 3963L, 5615L, 3551L, 4789L,         3757L, 4307L, 3207L, 5752L, 5890L, 5684L, 6234L, 4445L,         4927L, 4927L, 4652L, 4032L, 3551L, 5340L, 6303L, 5821L,         6440L, 6028L, 5821L, 4032L, 6028L, 4927L, 5752L, 4032L,         4376L, 5890L, 4032L, 6441L, 3826L, 4720L, 3069L, 6234L,         6165L, 4996L, 3482L, 5133L, 3276L, 4858L, 6234L, 3688L,         4170L, 5064L, 4996L, 4239L, 6440L, 5890L, 5959L, 4789L,         3688L, 3138L, 3138L, 5615L, 3482L, 5340L, 3620L, 5271L,         6372L, 4514L, 6372L, 6372L, 4583L, 4239L, 4308L, 3207L,         3413L, 4239L, 3551L, 5408L, 3620L, 4652L, 6441L, 4445L,         3482L, 5271L, 6165L, 5133L, 5133L, 4996L, 3757L, 6028L,         6441L, 4996L, 6303L, 5202L, 5340L, 5615L), sdimy = c(-4125L,         -2808L, -5202L, -5322L, -4604L, -3047L, -4724L, -2928L,         -3047L, -4125L, -2688L, -3047L, -4125L, -4005L, -4125L,         -2569L, -3167L, -3646L, -4724L, -4484L, -5442L, -4604L,         -4125L, -4843L, -3526L, -5202L, -2808L, -4005L, -4245L,         -3526L, -2568L, -5082L, -3885L, -4723L, -4125L, -2928L,         -4125L, -3526L, -4245L, -4963L, -4484L, -3766L, -3287L,         -4843L, -2808L, -4604L, -5083L, -4244L, -5202L, -3287L,         -5322L, -3047L, -5202L, -3287L, -2928L, -4245L, 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